Pelagoniski
- Population: 236,088
- Area in km2: 4.717
- Number of municipalities: 9
- Number of settlements: 343
Vardar
- Population: 154,230
- Area in km2: 4.042
- Number of municipalities: 9
- Number of settlements: 215
Southeast
- Population: 171,972
- Area in km2: 2.739
- Number of municipalities: 10
- Number of settlements: 188
East
- Population: 180,938
- Area in km2: 3.537
- Number of municipalities: 11
- Number of settlements: 217
Northeast
- Population: 173,982
- Area in km2: 2.310
- Number of municipalities: 6
- Number of settlements: 192
Skopje
- Population: 590,455
- Area in km2: 1.812
- Number of municipalities: 17
- Number of settlements: 142
Poloski
- Population: 310,178
- Area in km2: 2.416
- Number of municipalities: 9
- Number of settlements: 184
Southwest
- Population: 222,385
- Area in km2: 3.340
- Number of municipalities: 9
- Number of settlements: 286